SPRAVATO™ is a prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults. If you’ve struggled with depression and tried two or more antidepressants* in your current episode without adequate relief, talk to your doctor to see if you have treatment-resistant depression. Those who took SPRAVATO™ and an oral antidepressant experienced greater reductions of depression symptoms at four weeks compared to those who received a placebo plus an oral antidepressant